Professor S. Tavaré

Career

  • 2013 - present Director, Cancer Research UK Cambridge Institute
  • 2006 - present Senior Group Leader, Cancer Research UK Cambridge Institute
  • 2003 - present Professor, DAMTP
  • 2003 - present Professor of Cancer Research (Bioinformatics), Department of Oncology
  • 1999 - 2006 Professor, Department of Preventive Medicine, University of Southern California
  • 1989 - 2006 Professor, Departments of Mathematics and Biological Sciences, University of Southern California
  • 1984 - 1989 Associate Professor, Department of Mathematics, University of Utah
  • 1981 - 1985 Assistant & Associate Professor, Department of Statistics, Colorado State University
  • 1978 - 1981 Instructor, Department of Mathematics, University of Utah

Research

Cancer genomics; evolutionary approaches to cancer; statistical bioinformatics for arrays and sequencing; computational biology; population genetics, coalescent theory; stochastic computation, approximate Bayesian computation; statistical inference in molecular biology, human genetics, molecular evolution, palaeontology; tracking from videos; probabilistic combinatorics. FMedSci 2009; FRS 2011; Member of EMBO 2015.

Selected Publications

  • Josephidou M, Lynch AG & Tavare S. multiSNV: a probabilistic approach for improving detection of somatic point mutations from multiple related tumour samples. Nucleic Acids Research, doi:10.1093/nar/gkv135, 2015.
  • Sottoriva A, Spiteri I, Piccirillo SGM, Touloumis A, Collins VP, Marioni JC, Curtis CN, Watts C & Tavaré S. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci USA, 110, 4009-4014, 2013.
  • Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Graf S, Ha G, Ha ari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerod A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Brresen-Dale A-L, Brenton J, Tavaré S, Caldas C & Aparicio S. The genomic and transcriptomic architecture of 2000 breast tumours reveals novel subgroups. Nature, 486, 346-352, 2012.
  • Cairns J, Spyrou S, Stark R, Smith ML, Lynch AG & Tavaré S. BayesPeak - An R package for analysing ChIP-seq data. Bioinformatics, 27, 713–714, 2011.
  • Wilkinson RD, Steiper M, Soligo C, Martin R, Yang Z & Tavaré S. Dating primate divergences through an integrated analysis of palaeontological and molecular data. Systematic Biology, 60, 16–31, 2011.
  • Siegmund KD, Marjoram P, Woo Y-J, Tavaré S & Shibata D. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci USA, 106, 4828–4833, 2009.
  • Arratia R, Barbour AD & Tavaré S. Logarithmic Combinatorial Structures: A Probabilistic Approach. EMS Monographs in Mathematics, 1, 2003. European Mathematical Society Publishing House, Zuerich.
  • Marjoram P, Molitor J, Plagnol V & Tavaré S. Markov chain Monte Carlo without likelihoods. Proc. Natl. Acad. Sci. USA, 100, 15324–15328, 2003.