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Department of Applied Mathematics and Theoretical Physics

Dr Steph Höhn

Personal Homepage: http://www.damtp.cam.ac.uk/user/sh753/index.html

Career

  • 2013-: Postdoctoral researcher, DAMTP, University of Cambridge
  • 2009-2013: Doctoral student, Department for Cellular and Developmental Biology of Plants, Bielefeld University, DE
  • 2003-2009: Bachelor/Master student, Bielefeld University, DE

Research

How do cells generate the forces that shape our tissues and organs? In developing embryos, its cells move and change their shape in an astoundingly coordinated way. We need to understand the underlying mechanics, as errors in this self-organisation can lead to severe birth defects. Many tissues, including the primal gut, the neural tube and our retina, are formed through Cell Sheet Folding. I combine advanced imaging, experiments and computational modelling to reveal biophysical and mechano-chemical mechanisms underlying Cell Sheet Folding.

 

Publications

  • Thomas C. Day, Stephanie S.M.H. Höhn, Seyed A. Zamani-Dahaj, David Yanni, Anthony Burnetti, Jennifer Pentz, Aurelia R. Honerkamp-Smith, Hugo Wioland, Hannah R. Sleath, William C. Ratcliff, Raymond E. Goldstein, and Peter J. Yunker. Cellular Organization in Lab-Evolved and Extant Multicellular Species Obeys a Maximum Entropy Law. eLife, in press. [OA]: https://www.biorxiv.org/content/10.1101/2021.07.29.454238v1

 

  • Daniele Agostinelli, Robert Cerbino, Juan C. Del Alamo, Antonio DeSimone, Stephanie S.M.H.  Höhn, Cristian Micheletti, Giovanni Noselli, Eran Sharon and Julia Yeomans. MicroMotility: state of the art, recent accomplishments and perspectives on the mathematical modeling of bio-motility at microscopic scales. Mathematics in Engineering 2(2): 230 (2020).

[OA]: https://www.aimspress.com/article/10.3934/mine.2020011

 

  • Pierre A. Haas*, Stephanie S.M.H.  Höhn*, Aurelia E. Honerkamp-Smith, Julius B. Kirkegaard and Raymond E. Goldstein. The noisy basis of morphogenesis: mechanisms and mechanics of cell sheet folding inferred from developmental variability. PLOS Biology 16, e2005536 (2018).

[OA]: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005536

* Equal contribution. 

 

  • Stephanie S.M.H. Höhn and Armin Hallmann, Distinct shape-shifting regimes of bowl-shaped cell sheets – embryonic inversion in the multicellular green alga Pleodorina californica, BMC Developmental Biology, 16:35 (2016).

[OA]: https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-016-0134-9

 

  • Stephanie S.M.H.  Höhn, Aurelia E. Honerkamp-Smith, Pierre A. Haas, Philipp Khuc Trong, and Raymond E. Goldstein, Dynamics of a Volvox embryo turning itself inside out, Physical Review Letters 114, 178101 (2015).  

[OA]: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.114.178101

 

See also Physics Viewpoint by A. Boudaoud, Physics 8, 39 (2015). https://physics.aps.org/articles/v8/39

 

  • Stephanie S.M.H. Höhn and Armin Hallmann. There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator, BMC Biology, 9:98 (2011).

[OA]: https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-9-89

 

See also BMC Biology Commentary by R. Keller and D. Shook, BMC Biology, 9: 90 (2011). https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-9-9

Publications

The noisy basis of morphogenesis: Mechanisms and mechanics of cell sheet folding inferred from developmental variability
PA Haas, SSMH Höhn, AR Honerkamp-Smith, JB Kirkegaard, RE Goldstein
– PLOS Biology
(2018)
16,
e2005536
(doi: 10.1371/journal.pbio.2005536)
Distinct shape-shifting regimes of bowl-shaped cell sheets - embryonic inversion in the multicellular green alga Pleodorina.
S Höhn, A Hallmann
– BMC Developmental Biology
(2016)
16,
35
(doi: 10.1186/s12861-016-0134-9)
Dynamics of a Volvox embryo turning itself inside out
S Höhn, AR Honerkamp-Smith, PA Haas, PK Trong, RE Goldstein
– Physical review letters
(2015)
114,
178101
(doi: 10.1103/physrevlett.114.178101)
Using in vivo Optical Sectioning to Investigate Mechanical Aspects of Volvox Development
AR Honerkamp-Smith, S Hoehn, H Wioland, PA Haas, PK Trong, RE Goldstein
– Biophysical Journal
(2015)
108,
459a
(doi: 10.1016/j.bpj.2014.11.2506)
There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator.
S Höhn, A Hallmann
– BMC biology
(2011)
9,
89
(doi: 10.1186/1741-7007-9-89)

Research Group

Biological Physics and Mechanics

Email

S.Hoehn@damtp.cam.ac.uk

Room

H0.03

Telephone

01223 337859

Study at Cambridge

About the University

Research at Cambridge